Pierre Milbeo

Pierre Milbeo

Maître de Conférences

Chargé (e) de cours , Webmestre

  • Adresse : CY Cergy Paris Université Site de Neuville-sur-Oise Batiment F 5 mail Gay Lussac 95000 Neuville-sur-Oise
Domaines d'expertise
  • Organic synthesis
  • Asymmetric catalysis
  • Synthesis and conformational analysis of peptides and peptidomimetics
  • Radical chemistry

Discipline(s) enseignée(s)

  • Chimie générale
  • Synthèse organique
  • Techniques d'analyse

Activités / CV

Professional experience :

  • Sept 2021-Present : Associate Professor at CY Cergy-Paris Université/BioCIS-ECB
  • Nov 2020- June 2021: Postdoctoral fellow INSA-Rouen
    Group of Dr Levacher and Dr Brière, UMR COBRA, Université de Rouen, France
  • June-Nov 2020 : Postdoctoral fellow INSA-Rouen/Oril Industrie (Servier)
    Laboratoire commun IDECHEM, UMR COBRA, Université de Rouen, France
  • 2018-2020: Science Foundation Ireland Postdoctoral Fellow
    Group of Prof. Eoin Scanlan, School of Chemistry, Trinity College Dublin, Ireland
  • 2014-2017: PhD student University of Montpellier
    Group of Dr. Monique Calmès, Institut des Biomolécules Max Mousseron (IBMM), France
  • Sept 2013-May 2014: Final year master project
    Group of Prof. Nicholas Westwood, School of chemistry, University of St Andrews, UK
  • July-August 2013: Two-month placement
    Group of Prof. Mark Bagley, School of life science, University of Sussex, Brighton, UK


  • 2014-2017: Université de Montpellier, Hérault, France. PhD
  • 2013-2014: University of St Andrews, Scotland, UK. MChem degree within an exchange program with ENSCL
  • 2013-2014: Université de Lille 1, Nord, France. Master in chemistry and biology with organic chemistry.
  • 2011-2014: Ecole Nationale Supérieure de Chimie de Lille (ENSCL), Nord, France. Engineering degree in Chemistry

Funded research projects and awards :

  • Selected member of the EUTOPIA Young Leader Academy (2nd cohort : 2023-2025)
  • CY Initiative Emergence : FAstPhox 2022-2024 "Fluorinated peptides as organocatalysts in asymmetric photoredox reactions"

Peer-reviewed scientific publications

13 publications (h-index = 5, 89 citations)

  • Asymmetric α-Fluoroalkyl-α-Amino Acids: Recent Advances in Their Synthesis and Applications, Picois, N.; Boutahri, Y.; Milbeo, P.; Zanato, C.; Lensen, N.; Chaume, G; Brigaud, T.; Molecules, 2024, 29(6), 1408 (IF : 4.6)
  • Bimodal use of chiral α-Trifluoromethylalanine in Aib Foldamers: study of the position impact towards the helical screw-sense preference, Picois, N.; Bodero, L.; Milbeo, P.; Brigaud, T.; Chaume, G; Chem. Eur. J. 2024, e202400540 (IF: 5.02)
  • An organocatalytic and stereoselective vinylogous domino process towards thiochromans. Milbeo, P.; Lebrêne, A.; Savchuk, M.; Vo-Thanh, G.; Oudeyer, S.; Beucher, H.; Brière, J.-F.; Chem. Eur. J. 2023, 29, 42, e202301311. (IF: 5.02)
  • Next generation Glucose-1-phosphate thhymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design. Xiao, G.; Alphey, M.S.; Tran F.; Pirrie, L.; Milbeo, P.; Zhou, Y.; Bickel, J.K.;Kempf, O.; Kempf, K.; Naismith, J.H.; Westwood,N.J.;  Bioorg. Med. Chem., 2021, 116477. (IF: 3.64)
  • Radical-mediated acyl-thiol-ene ligation for rapid synthesis of biomolecular thioester derivatives. Milbeo, P.; McLean, J.T.; McSweeney, L.; Scanlan, E.M.; Eur. J. Org. Chem. 2021, 4148-4160. (IF: 3.02)
  • 2-Aminobicyclo[2.2.2]octane-2-carboxylic acid and derivatives as chiral constrained bridged scaffolds for foldamers and chiral catalysts, Milbeo, P.; Martinez, J.; Amblard, M.; Calmès, M.; Legrand, B.; Acc. Chem. Res. 2021, 54, 3, 685-696  (IF:  21.66)
  • Synthesis, characterisation and cytotoxic activity evaluation of new metalsalen complexes based on the 1,2-bicyclo[2.2.2]octane bridge. Milbeo, P.; Quintin, F.; Moulat, L.; Didierjean, C.; Martinez, J.; Bantreil, X.; Calmès, M.; Lamaty, F.; Tetrahedron Letters, 2021, 63, 152706, Preprint on ChemRxiv (IF: 2.27)
  • A bicyclic unit reversal to stabilize the 12/14-helix in mixed homochiral oligoureas; Milbeo, P.; Simon, M.; Didierjean, C.; Wenger, E.; Aubert, E.; Amblard, M.; Calmès, M.; Legrand, B.; Chem.Commun, 2020, 56, 7921 (IF: 6.16)
  • 12/10-helix in mixed β-peptides alternating bicyclic and acyclic β-amino acids: probing the relationship between bicyclic side chain and helix stability; Simon, M.; Milbeo, P.; Liu, H.; André, A.; Wenger, E.; Martinez, J.; Amblard, M.; Aubert, E.; Legrand, B.; Calmès, M. Chem. Eur. J. 2018, 24, 70, 18795. (IF: 5.16)
  • C1-Symmetric 1,2-Diaminobicyclo[2.2.2]octane Ligands in Copper-Catalyzed Asymmetric Henry Reaction: Catalyst Development and DFT Studies; Milbeo, P.; Moulat, L.; Didierjean, C.; Aubert, E.; Martinez, J.; Calmès, M. Eur. J. Org. Chem. 2018, 2, 178. (IF: 2.83)
  • Synthesis of Enantiopure 1,2-Diaminobicyclo[2.2.2]octane Derivatives, C1-Symmetric Chiral 1,2-Diamines with a Rigid Bicyclic Backbone; Milbeo, P.; Moulat, L.; Didierjean, C.; Aubert, E.; Martinez, J.; Calmès, M.  J. Org. Chem. 2017, 82 (6), 3144. (IF: 4.8)
  • N-Pyrrolidine-based α/β-peptides incorporating ABOC, a constrained bicyclic β-amino acid, for asymmetric aldol reaction catalysis; Milbeo, P.; Maurent, K.; Moulat, L.; Lebrun, A.; Didierjean, C.; Aubert, E.; Martinez, J.; Calmès, M. Tetrahedron 2016, 72 (13), 1706. (IF: 2.64)
  • Microwave-assisted synthesis of MK2 inhibitors for targeting p38 MAPK signal transduction in Werner syndrome cells; Bagley, M. C.; Baashen, M.; Dwyer, J.; Milbeo, P.; Kipling, D.; Davis, T. In Microwaves in Drug Discovery and Development: Recent Advances; Future Science Book Series; Future Science Ltd, 2014; pp 86–104. (IF: 3.55) (Chapitre de eBook)