Chiara ZANATO

Chiara ZANATO

Associate Professor

  • Adresse : BioCIS, UMR 8076, Equipe de Chimie Biologique. 5 Mail Gay-Lussac, Neuville sur Oise 95031 Cergy-Pontoise, France
Domaines d'expertise
Organic Chemistry, Medicinal Chemistry, Chemical Biology
  • Synthesis of bioactive molecules as molecular tools for studying biological processes
  • Peptides and Pseudopeptides
  • Total Synthesis of natural compounds
  • 18F-labeled PET tracers
  • Cannabinoids Receptors

Activités / CV

2005 – BSc in Chemistry at the University of Milan (Italy)
2007 – MSc in Chemical Sciences at the University of Milan (Italy)
2007 – 2010: PhD in Organic Chemistry (group of Professor C.Gennari) University of Milan (Italy)
2011 – 2017: Research fellow (group of Professor M. ZANDA), University of Aberdeen (UK)
2017 – 2018: Postdoc (group of Professor T. BRIGAUD) at BioCIS, CY Cergy Paris Université (FR)
2018 – 2020: Ingénieur de Recherche at BioCIS, CY Cergy Paris Université (FR)
2020 –Present: Associate Professor at BioCIS, CY Cergy Paris Université (FR)

Representative Publications:
  • The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators. 
    J. Med. Chem. 2019, 62, 5049–5062.
    https://doi.org/10.1021/acs.jmedchem.9b00252

  • Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus. 
    Nature 2018, 555, 382-386. 
    https://doi.org/10.1038/nature25974

  • Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers. 
    Org. Biomol. Chem. 2017, 15, 2086-2096.
    https://doi.org/10.1039/C6OB02796B

  • A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects. 
    Neuropsychopharmacology 2015, 40, 2948-2959.
    https://doi:10.1038/npp.2015.148

  • Highly stereoselective total synthesis of (+)-9-epi-Dictyostatin and (-)-12,13-Bis-epi-dictyostatin.
    Eur. J. Org. Chem. 2011, 2643-2661. 
    https://doi.org/10.1002/ejoc.201100244

Informations complémentaires